3zim: Difference between revisions
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==Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha== | ==Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha== | ||
<StructureSection load='3zim' size='340' side='right' caption='[[3zim]], [[Resolution|resolution]] 2.85Å' scene=''> | <StructureSection load='3zim' size='340' side='right' caption='[[3zim]], [[Resolution|resolution]] 2.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3zim]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3zim]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZIM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ZIM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KKR:1-[4-[[2-(1H-INDAZOL-4-YL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDIN-6-YL]METHYL]PIPERAZIN-1-YL]-6-METHYL-HEPT-5-ENE-1,4-DIONE'>KKR</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KKR:1-[4-[[2-(1H-INDAZOL-4-YL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDIN-6-YL]METHYL]PIPERAZIN-1-YL]-6-METHYL-HEPT-5-ENE-1,4-DIONE'>KKR</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zim OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3zim RCSB], [http://www.ebi.ac.uk/pdbsum/3zim PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3zim FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zim OCA], [http://pdbe.org/3zim PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3zim RCSB], [http://www.ebi.ac.uk/pdbsum/3zim PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3zim ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 3zim" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Bhavsar, D]] | [[Category: Bhavsar, D]] | ||
[[Category: Blaesse, M]] | [[Category: Blaesse, M]] | ||