TolB: Difference between revisions

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==The TolB-Pal Complex==
==The TolB-Pal Complex==
<structure load='2w8b' size='300' align='left' caption='Interaction of TolB (grey, green, yellow, cyan) and peptoglycan-associated lipoprotein (Pal) (pink, magenta, gold, red), sulfate, acetate and glycerol [[2w8b]]' (PDB entry [[2w8b]] >
 


The TolB-[[Pal]] complex is involved in maintaining the outer membrane integrity.  Upon binding, TolB and Pal undergo a conformational change , the result of which is crucial for further interactions with other proteins<ref name='Godlewska'>PMID: 19519769</ref>.  This complex is parasitised by protein antibiotics  and disrupted in order to trigger the translocation of the toxin across the outer membrane (see [[Colicin]] for further information)<ref name='Bonsor'>PMID: 17375930</ref>.
The TolB-[[Pal]] complex is involved in maintaining the outer membrane integrity.  Upon binding, TolB and Pal undergo a conformational change , the result of which is crucial for further interactions with other proteins<ref name='Godlewska'>PMID: 19519769</ref>.  This complex is parasitised by protein antibiotics  and disrupted in order to trigger the translocation of the toxin across the outer membrane (see [[Colicin]] for further information)<ref name='Bonsor'>PMID: 17375930</ref>.