Transposase: Difference between revisions
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== Function == | == Function == | ||
'''Transposases''' bind to the ends of a transposon and catalyze its movement to another part of the genome by a cut-and-paste mechanism. Transposase contains a DDE motif in its active site enabling it to coordinate the binding of divalent metal ions. The metal ions affect transposase reactivity. | '''Transposases''' bind to the ends of a transposon and catalyze its movement to another part of the genome by a cut-and-paste mechanism. Transposase contains a DDE motif in its active site enabling it to coordinate the binding of divalent metal ions. The metal ions affect transposase reactivity. <br /> | ||
'''Mu transposase''' (MuA) is essential for integration, replication-transposition and excision of bacteriophage Mu DNA into multiple sites of bacterial genome. Mu transposition occurs within the transposome which is a protein-DNA complex which includes 4 subunits of MuA. | *'''Mu transposase''' (MuA) is essential for integration, replication-transposition and excision of bacteriophage Mu DNA into multiple sites of bacterial genome. Mu transposition occurs within the transposome which is a protein-DNA complex which includes 4 subunits of MuA.<br /> | ||
*'''Hermes transposase''' is a fly protein.<br /> | |||
* '''Dra2 transposase''' is a ''Deinococcus radiodurans'' protein<br /> | |||
*'''Tn5 transposase''' active site contains the DDE motif which catalyzes the movement of the transposon<br /> | |||
*'''Mos1 transposase''' mediates the movement of Mos1 transposon<br /> | |||
*'''Tc3 transposase''' mediates the movement of Tc3 transposon in ''C. elegans''<br /> | |||
== Disease == | == Disease == | ||
