4qyk

Crystal structure of a canine parvovirus variant

spinqualitylabelsall models 4qyk, resolution 3.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4qyk is a 30 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: MG Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Canine parvovirus (CPV-2) emerged in 1978 and spread worldwide within two years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids. Global displacement of canine parvovirus by a host-adapted variant: A structural comparison between pandemic viruses with distinct host ranges.,Organtini LJ, Allison AB, Lukk T, Parrish CR, Hafenstein S J Virol. 2014 Nov 19. pii: JVI.02611-14. PMID:25410876 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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