Virus protease

Virus proteases include HIV protease, XMRV protease, retropepsin. HIV Protease (HIV-PR) and xenotropic murine leukemia virus protease (XMRV-PR) cleave polyproteins to produce the mature proteins of the virus. Both are aspartyl proteases. The inhibition of HIV-PR results in an uninfectious HIV virion. HIV-1 is found globally while HIV-2, which has lower virulence, is found in West Africa. See also

• Human Immunodeficiency Virus
  
• HIV-1 protease
  
• HIV Protease Inhibitor Pharmacokinetics
  
• HIV Protease Inhibitor Resistance Profile
  
• HIV Protease Resistance
  
• Molecular Playground/Dengue Virus Protease
  
• Viability of a drug-resistant HIV-1 protease mutant
  
• Molecular Playground/Dengue Virus Protease

3D Structures of Virus proteases

Updated on 25-June-2015

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• HIV-1 protease
  • 3ixo - HIV1-PR subtype A
    
  • 1odx, 2hb2, 2hb4, 2pc0, 3bva, 3mws, 3kt2, 3kt5, 4ej8, 4ejl - HIV1-PR (mutant)
    
  • 1rpi, 1rq9, 1tw7, 3oq7, 3oqa, 3oqd, 3pj6, 3uf3, 3o99, 3o9a, 3o9b, 3o9c, 3o9d, 3o9e, 3o9f, 3o9g, 3o9h, 3o9i, 3u71 - HIV1-PR (drug-resistant mutant)
    
  • 1odw, 3kf1, 3hvp, 3phv - HIV1-PR
    
  • 3fsm, 3hlo - HIV1-PR covalent dimer
• HIV-1 protease complexes
  • 1hsg, 1hsh, 1hsi, 3oxc, 3ekv, 3ekx, 3eky, 3el1, 1ohr, 3ndt, 3nls, 3qoz, 3ndu, 3ndw, 3ndx, 3qoz, 3r0w, 3r0y, 4dqb, 4jec, 4hla - HIV1-PR + antiviral drug
    
  • 4eyr, 4j54, 4j55, 4j5j - HIV1-PR (mutant) + antiviral drug
    
  • 1aid, 1qbr, 1qbs, 1qbt, 1qbu, 3mxe, 3m9f , 3kf0, 3kf1, 3kfn, 3kfp, 3kfr, 3kfs, 2wkz, 2wl0, 3gga, 3ggv, 3ggx, 2uxz, 2uy0, 1zp8, 1xl2, 1xl5, 1zpa, 1yt9, 2a4f, 1upj, 2upj, 7upj, 1hxb, 1hih, 1hvr, 1hef, 1heg, 4phv, 1w5w, 1w5x, 1w5v, 1w5y, 1t7k, 1npa, 1npv, 1npw, 1eby, 1ec0, 1g2k, 1c6x, 1c6y, 1c6z, 1hwr, 2bpv, 2bpw, 2bpx, 2bpy, 2bpz, 1ody, 1hvh, 3tlh, 1hxw, 3bvb, 3ckt, 3mxd, 3hau, 3haw, 3hbo, 3hdk, 3i2l, 3ia9, 3r4b, 3bgb, 3bgc, 3bhe, 3gi4, 3gi5, 3gi6, 3nwq, 3nwx, 3nyg, 3psu, 3t11, 4fe6, 4a4q, 4i8w, 4i8z - HIV1-PR + inhibitor
    
  • 2zye - HIV1-PR + inhibitor - neutron
    
  • 3aid, 1ytg, 1yth, 2nxd, 2nxl, 2nxm, 2fns, 2fnt, 1zj7, 1zlf, 1zpk, 1zsf, 1zsr, 1cpi, 1m0b, 1iiq, 1fqx, 1a30 - HIV1-PR + polypeptide derivative
    
  • 3gi0 - HIV1-PR covalent dimer + polypeptide
    
  • 3hzc, 3iaw, 3ka2, 3nxn - HIV1-PR covalent dimer + inhibitor
    
  • 1sp5 - HIV1-PR + autoproteolytic peptide
    
  • 4ep2, 4epj, 4eq0, 4eqj - HIV1-PR + substrate
    
  • 4ejd, 4ejk - HIV1-PR + pepstatin
    
  • 4f73- HIV1-PR + CA-P2
    
  • 4f74- HIV1-PR + MA-CA
    
  • 4f75- HIV1-PR + RH-IN
    
  • 4f76- HIV1-PR + P1-P6
    
• HIV-1 protease (mutant) complexes
  • 3nu3, 3nu4, 3nu5, 3nu6, 3nu9, 3nuj, 3nuo, 2qhc, 2qak, 2pym, 2pyn, 2q63, 2q64, 2fxd, 2fxe, 2fgu, 2fgv, 1sdt, 1sdu, 1sdv, 1d4y, 1d4s, 3cyw, 3cyx, 3d1x, 3d1y, 3d1z, 3d20, 3djk, 3dk1, 3n3i, 3oxv, 3oxw, 3oxx, 3oy4, 3k4v, 3lzs, 3lzu, 3lzv, 3so9, 3spk, 3ufn, 4dqh, 3s43, 3s53, 3s54, 3s56, 4dqc, 4dqe, 4dqf, 4dqg - HIV1-PR (mutant) + antiviral drug
    
  • 2aid, 1hpo, 1tcx, 1gnm, 1gnn, 1gno, 1kzk, 3ok9, 3i8w, 3i7e, 3bxr, 3bxs, 2hc0, 2psu, 2psv, 2fle, 2f3k, 2ien, 2fdd, 2fde, 1t7i, 1t3r, 1mrw, 1mrx, 1msm, 1msn, 1bv9, 3h5b, 3kdb, 3kdc, 3kdd, 3a2o, 3bc4, 3fx5, 3i6o, 3st5, 3qaa, 3qbf, 3qih, 3qn8, 3qp0, 3qpj, 3qrm, 3qro, 3qrs, 4dfg - HIV1-PR (mutant) + inhibitor
    
  • 2p3b - HIV1-PR subtype B (mutant) + inhibitor
    
  • 2p3c - HIV1-PR subtype F (mutant) + inhibitor
    
  • 1zbg, 1z8c, 2az9, 2azc, 2a1e, 1lzq, 1d4k, 1d4l, 1a8k, 1a94, 1axa, 3dox, 3d3t, 4fl8 - HIV1-PR (mutant) + polypeptide derivative
    
  • 1ztz - HIV1-PR (mutant) + autoproteolytic polypeptide + metalacarborane
    
  • 3b7v, 3b80, 3mim - HIV1-PR (mutant) + autoproteolytic polypeptide + tetrahedral intermediate
    
  • 3nxe - HIV1-PR covalent dimer (mutant) + inhibitor
    
  • 4flg, 4fm6 - HIV1-PR (mutant) + reaction intermediate
• HIV-1 protease (drug-resistant mutant) complexes
  • 3el4, 3el9, 3em3, 3em4, 3em6, 3ggt, 3ggu, 1t7j, 1rv7, 1n49, 1fb7, 3ekp, 3ekq, 3ekt, 3ekw, 3el0, 3el5, 3pwm, 3pwr, 3ucb, 3uhl, 3ttp - HIV1-PR (drug-resistant mutant) + antiviral drug
    
  • 3ots, 3oty, 3ou1, 3ou3, 3ou4, 3oua, 3oub, 3ouc, 3oud - HIV1-PR (drug-resistant mutant) + peptide
    
  • 1izh, 1izi, 1fb7, 3t3c, 4fae, 4faf, 3sa3, 3sa4, 3sa5, 3sa6, 3sa7, 3sa8, 3sa9, 3saa, 3sab, 3sac, 3vf5, 3vf7, 3vfa, 3vfb - HIV1-PR (drug-resistant mutant) + inhibitor
    
  • 2p3a - HIV1-PR subtype B (drug-resistant mutant) + inhibitor
    
  • 2p3d - HIV1-PR subtype F (drug-resistant mutant) + inhibitor
    
• HIV-2 protease
  • 1jld - HIV2-PR
    
  • 1hii - HIV2-PR + inhibitor
    
  • 5upj, 6upj, 3upj, 4upj - HIV2-PR (mutant) + inhibitor
    
  • 1ida, 1idb, 2mip - HIV2-PR + polypeptide derivative
• Feline Immunodeficiency virus protease

• • 2hah, 4fiv - FIV-PR residues 39-154 (mutant) + inhibitor
    
  • 3ogp, 3ogq - FIV-PR residues 39-154 (mutant) + drug
    
  • 5fiv, 6fiv, 1b11 - FIV-PR + inhibitor
    
  • 2fiv, 3fiv - SIV-PR (mutant) + substrate

• Simian Immunodeficiency virus protease

• • 2sam - SIV-PR + inhibitor
    
  • 1az5 - SIV-PR (mutant)
    
• Xenotropic murine leukemia virus protease
  • 3nr6 – XMRV-PR P14
    
  • 3p1g – XMRV-PR RNase H domain (mutant)
• Rous sarcoma virus protease
  • 1bai – RSVP + polypeptide inhibitor _ Rous sarcoma virus
• Human Cytomegalovirus protease
  • 1cmv, 1lay – CMVP (mutant) – human herpes virus 5
    
  • 1wpo – CMVP
    
  • 2wpo - CMVP (mutant) + inhibitor
• Varicella-Zoster virus protease
  • 1vzv - VZVP (mutant) – human herpes virus
• Equine infectious anemia virus protease
  • 2fmb – EIAVP (mutant) + inhibitor
• Hepatitis A virus protease
  • 2h9h – HAVP residues 1520-1731 (mutant) + polypeptide inhibitor
• Hepatitis C virus protease
  • 2o8m – HCVP (mutant)
    
• Orf 17
  • 3njq – hOrf 17 - human herpes virus 8
• Dengue virus protease
  • 3u1i – DvNs2b + peptide – Dengue virus
    
  • 3u1j – DvNs2b + BPTI
    
  • 2fom - DvNs2b + DvNs3
    
  • 2whx – DvNs3 residues 1475-2092
• Herpes simplex virus protease
  • 1at3 – HSV II – human herpesvirus 2
• Foot-and-Mouth Disease virus protease
  • 2bhg – FMDV – Foot-and-mouth disease virus
• Infectious Bronchitis virus protease
  • 2q6d – IBV – infectious bronchitis virus
    
  • 2q6f – IBV + inhibitor
• Yellowtail ascites virus protease
  • 4izj, 4izk – YAV Vp4 (mutant) – yellowtail ascites virus
• Pseudorabies virus protease
  • 4cx8 – YAV – pseudorabies virus
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman