4x7i: Difference between revisions

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'''~~Unreleased~~ structure'''

==Crystal Structure of BACE with amino thiazine inhibitor LY2886721==

~~The entry~~ 4x7i is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4x7i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7I OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X7I FirstGlance].

~~Authors~~: Timm, D.E.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=3YS:N-{3-[(4AS,7AS)-2-AMINO-4A,5-DIHYDRO-4H-FURO[3,4-D][1,3]THIAZIN-7A(7H)-YL]-4-FLUOROPHENYL}-5-FLUOROPYRIDINE-2-CARBOXAMIDE'>3YS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </td></tr>

~~Description~~: ~~BACE crystal structure with amino amidine~~ inhibitor

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x7i RCSB], [http://www.ebi.ac.uk/pdbsum/4x7i PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Memapsin 2]]

[[Category: Timm, D E]]

[[Category: Bace]]

[[Category: Beta-secretase]]

[[Category: Complex]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Inhibitor]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal Structure of BACE with amino thiazine inhibitor LY2886721==
+<StructureSection load='4x7i' size='340' side='right' caption='[[4x7i]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
-The entry 4x7i is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4x7i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4X7I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4X7I FirstGlance]. <br>
-Authors: Timm, D.E.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3YS:N-{3-[(4AS,7AS)-2-AMINO-4A,5-DIHYDRO-4H-FURO[3,4-D][1,3]THIAZIN-7A(7H)-YL]-4-FLUOROPHENYL}-5-FLUOROPYRIDINE-2-CARBOXAMIDE'>3YS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
-Description: BACE crystal structure with amino amidine inhibitor
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4x7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4x7i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4x7i RCSB], [http://www.ebi.ac.uk/pdbsum/4x7i PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Memapsin 2]]
+[[Category: Timm, D E]]
+[[Category: Bace]]
+[[Category: Beta-secretase]]
+[[Category: Complex]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Inhibitor]]