1p39: Difference between revisions
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|PDB= 1p39 |SIZE=350|CAPTION= <scene name='initialview01'>1p39</scene>, resolution 2.0Å | |PDB= 1p39 |SIZE=350|CAPTION= <scene name='initialview01'>1p39</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5 | |LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=MGT:7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE'>MGT</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] | |ACTIVITY= [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] | ||
|GENE= | |GENE= | ||
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[[Category: vaccinia]] | [[Category: vaccinia]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:09:35 2008'' | ||
Revision as of 11:09, 23 March 2008
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| 1p39, resolution 2.0Å | |||||||||||||
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| Ligands: | SAH and MGT | ||||||||||||
| Activity: | Polynucleotide adenylyltransferase, with EC number 2.7.7.19 | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG
Overview
The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.
About this Structure
1P39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.
Reference
Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:9145102
Page seeded by OCA on Sun Mar 23 13:09:35 2008
