1p57: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p57 OCA], [http://www.ebi.ac.uk/pdbsum/1p57 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p57 RCSB]</span> | |||
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[[Category: Sperandio, D.]] | [[Category: Sperandio, D.]] | ||
[[Category: Sprengeler, P A.]] | [[Category: Sprengeler, P A.]] | ||
[[Category: scavenger receptor cysteine-rich domain]] | [[Category: scavenger receptor cysteine-rich domain]] | ||
[[Category: serine protease]] | [[Category: serine protease]] | ||
[[Category: srcr]] | [[Category: srcr]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:55:08 2008'' | ||
Revision as of 19:55, 30 March 2008
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| 1p57, resolution 1.75Å | |||||||||||||
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| Ligands: | CR4 | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Extracellular domain of human hepsin
Overview
Hepsin is an integral membrane protein that may participate in cell growth and in maintaining proper cell morphology and is overexpressed in a number of primary tumors. We have determined the 1.75 A resolution structure of the extracellular component of human hepsin. This structure includes a 255-residue trypsin-like serine protease domain and a 109-residue region that forms a novel, poorly conserved, scavenger receptor cysteine-rich (SRCR) domain. The two domains are associated with each other through a single disulfide bond and an extensive network of noncovalent interactions. The structure suggests how the extracellular region of hepsin may be positioned with respect to the plasma membrane.
About this Structure
1P57 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain., Somoza JR, Ho JD, Luong C, Ghate M, Sprengeler PA, Mortara K, Shrader WD, Sperandio D, Chan H, McGrath ME, Katz BA, Structure. 2003 Sep;11(9):1123-31. PMID:12962630
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