2ma7: Difference between revisions

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== Structural highlights ==

<table><tr><td colspan='2'>[[2ma7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA7 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MA7 FirstGlance].

<table><tr><td colspan='2'>[[2ma7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA7 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MA7 FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">IKZF4, KIAA1782, ZNFN1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">IKZF4, KIAA1782, ZNFN1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ma7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ma7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ma7 PDBsum]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ma7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma7 OCA], [http://pdbe.org/2ma7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ma7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ma7 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/IKZF4_HUMAN IKZF4_HUMAN]] DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems.<ref>PMID:10978333</ref> <ref>PMID:12015313</ref> <ref>PMID:12444977</ref>

== References ==

__TOC__

</StructureSection>

[[Category: ~~Homo sapiens~~]]

[[Category: Human]]

[[Category: Acton, T B]]

[[Category: Everett, J K]]

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 <StructureSection load='2ma7' size='340' side='right' caption='[[2ma7]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2ma7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MA7 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2ma7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MA7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MA7 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IKZF4, KIAA1782, ZNFN1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IKZF4, KIAA1782, ZNFN1A4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ma7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ma7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ma7 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ma7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ma7 OCA], [http://pdbe.org/2ma7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ma7 RCSB], [http://www.ebi.ac.uk/pdbsum/2ma7 PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/IKZF4_HUMAN IKZF4_HUMAN]] DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems.<ref>PMID:10978333</ref> <ref>PMID:12015313</ref> <ref>PMID:12444977</ref>
+== References ==
+<references/>
 __TOC__
 </StructureSection>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Acton, T B]]
 [[Category: Everett, J K]]