1qa6: Difference between revisions
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|PDB= 1qa6 |SIZE=350|CAPTION= <scene name='initialview01'>1qa6</scene>, resolution 2.800Å | |PDB= 1qa6 |SIZE=350|CAPTION= <scene name='initialview01'>1qa6</scene>, resolution 2.800Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OS:OSMIUM+ION'>OS</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qa6 OCA], [http://www.ebi.ac.uk/pdbsum/1qa6 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qa6 RCSB]</span> | |||
}} | }} | ||
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[[Category: Gittis, A G.]] | [[Category: Gittis, A G.]] | ||
[[Category: Lattman, E E.]] | [[Category: Lattman, E E.]] | ||
[[Category: antibiotic binding]] | [[Category: antibiotic binding]] | ||
[[Category: minor groove binding]] | [[Category: minor groove binding]] | ||
[[Category: ribosomal rna]] | [[Category: ribosomal rna]] | ||
[[Category: tertiary structur]] | [[Category: tertiary structur,e rna-protein interaction]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:10:54 2008'' | ||
Revision as of 20:10, 30 March 2008
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| 1qa6, resolution 2.800Å | |||||||||||||
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| Ligands: | A, C, G, MG, OS, U | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX
Overview
The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome.
About this Structure
1QA6 is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.
Reference
Crystal structure of a conserved ribosomal protein-RNA complex., Conn GL, Draper DE, Lattman EE, Gittis AG, Science. 1999 May 14;284(5417):1171-4. PMID:10325228
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