3w2r: Difference between revisions

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==EGFR Kinase domain T790M/L858R mutant with compound 4==

== Structural highlights ==

<table><tr><td colspan='2'>[[3w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/~~Homo_sapiens Homo sapiens~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2R OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W2R FirstGlance].

<table><tr><td colspan='2'>[[3w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2R OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W2R FirstGlance].

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=W2R:1-{3-[2-CHLORO-4-({5-[2-(2-HYDROXYETHOXY)ETHYL]-5H-PYRROLO[3,2-D]PYRIMIDIN-4-YL}AMINO)PHENOXY]PHENYL}-3-CYCLOHEXYLUREA'>W2R</scene></td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">EGFR, ERBB, ERBB1, HER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 ~~Homo sapiens~~])</td></tr>

<tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">EGFR, ERBB, ERBB1, HER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w2r RCSB], [http://www.ebi.ac.uk/pdbsum/3w2r PDBsum]</td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2r OCA], [http://pdbe.org/3w2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w2r RCSB], [http://www.ebi.ac.uk/pdbsum/3w2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w2r ProSAT]</td></tr>

</table>

== Disease ==

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__TOC__

</StructureSection>

[[Category: ~~Homo sapiens~~]]

[[Category: Human]]

[[Category: Receptor protein-tyrosine kinase]]

[[Category: Igaki, S]]

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 ==EGFR Kinase domain T790M/L858R mutant with compound 4==
 <StructureSection load='3w2r' size='340' side='right' caption='[[3w2r]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W2R FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3w2r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W2R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3W2R FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=W2R:1-{3-[2-CHLORO-4-({5-[2-(2-HYDROXYETHOXY)ETHYL]-5H-PYRROLO[3,2-D]PYRIMIDIN-4-YL}AMINO)PHENOXY]PHENYL}-3-CYCLOHEXYLUREA'>W2R</scene></td></tr>
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3poz|3poz]], [[3w2o|3w2o]], [[3w2p|3w2p]], [[3w2q|3w2q]], [[3w2s|3w2s]]</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGFR, ERBB, ERBB1, HER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">EGFR, ERBB, ERBB1, HER1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3w2r RCSB], [http://www.ebi.ac.uk/pdbsum/3w2r PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3w2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3w2r OCA], [http://pdbe.org/3w2r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3w2r RCSB], [http://www.ebi.ac.uk/pdbsum/3w2r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3w2r ProSAT]</span></td></tr>
 </table>
 == Disease ==
@@ Line 20: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Homo sapiens]]
+[[Category: Human]]
 [[Category: Receptor protein-tyrosine kinase]]
 [[Category: Igaki, S]]