4bsz

Crystal Structure of the Yeast Ribosomal Protein Rps3 in Complex with its Chaperone Yar1

spinqualitylabelsall models 4bsz, resolution 2.84Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4bsz is a 2 chain structure with sequence from Saccharomyces cerevisiae w303. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Function [YAR1_YEAST] Required for normal rate of cell proliferation. Publication Abstract from PubMed Eukaryotic ribosome assembly involves a plethora of factors, which ensure that a correctly folded ribosome contains all ribosomal protein components. Among these assembly factors, Yar1 has recently emerged as a molecular chaperone for ribosomal protein rpS3 of the small ribosomal subunit (40S) in yeast. In complex with its chaperone, rpS3 is imported into the nucleus and protected from aggregation. How rpS3 and other ribosomal proteins are initially sequestered and subsequently integrated into pre-ribosomal particles is currently poorly understood. Here, we present the crystal structure of yeast rpS3 in complex with its chaperone Yar1 at 2.8A resolution. The crystal structure rationalizes how Yar1 can protect rpS3 from aggregation while facilitating nuclear import and suggests a mechanism for a stepwise exchange of molecular partners that ribosomal proteins interact with during ribosome assembly. Crystal Structure of the Yeast Ribosomal Protein rpS3 in Complex with Its Chaperone Yar1.,Holzer S, Ban N, Klinge S J Mol Biol. 2013 Sep 7. pii: S0022-2836(13)00542-1. doi:, 10.1016/j.jmb.2013.08.022. PMID:24021814 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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