4jek

Structure of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis

spinqualitylabelsall models 4jek, resolution 2.40Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4jek is a 8 chain structure with sequence from Rhodococcus sp. igts8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: soxC, dszC (Rhodococcus sp. IGTS8) Resources: FirstGlance, OCA, RCSB, PDBsum Function [SOXC_RHOSG] Part of a pathway to remove covalently bound sulfur from dibenzothiophene (DBT) without breaking carbon-carbon bonds. Sulfur dioxygenase which converts DBT to DBT-sulfone (DBTO2 or DBT 5,5-dioxide). Publication Abstract from PubMed Dibenzothiophene (DBT) and its derivatives are typical sulfur compounds found in fossil fuels. These compounds show resistance to the hydrodesulfurization treatment that is commonly used in industry. Dibenzothiophene monooxygenase (DszC) is responsible for the oxidation of DBT, which is the first and the rate-limiting step in the DBT enzymatic desulfurization 4S pathway. In this study, the crystal structure of DszC from Rhodococcus erythropolis DS-3 is reported. The crystal of native DszC belonged to space group P1, with unit-cell parameters a = 96.16, b = 96.27, c = 98.56 A, alpha = 81.03, beta = 67.57, gamma = 85.84 degrees . To determine the phase, SAD X-ray diffraction data were collected from a SeMet-derivative DszC crystal, which also belonged to space group P1, with unit-cell parameters a = 95.379, b = 95.167, c = 94.891 A, alpha = 87.046, beta = 70.536, gamma = 79.738 degrees . Further structural analysis of DszC is in progress. Crystallization and preliminary structural analysis of dibenzothiophene monooxygenase (DszC) from Rhodococcus erythropolis.,Duan X, Zhang L, Zhou D, Ji K, Ma T, Shui W, Li G, Li X Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):597-601. doi:, 10.1107/S1744309113011172. Epub 2013 May 23. PMID:23722833 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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