4ja4

Inward open conformation of the xylose transporter XylE from E. coli

spinqualitylabelsall models 4ja4, resolution 4.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 4ja4 is a 3 chain structure with sequence from Escherichia coli k-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: CD Related: 4ja3 Gene: xylE, b4031, JW3991 (Escherichia coli K-12) Resources: FirstGlance, OCA, RCSB, PDBsum Function [XYLE_ECOLI] Uptake of D-xylose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Publication Abstract from PubMed Here we present two structures of the major facilitator (MFS) xylose transporter XylE from Escherichia coli in inward open and partially occluded inward open conformations. These structures provide key information about the transport cycle of XylE and the closely related human GLUT transporters. This is, to our knowledge, the first MFS transporter structure determined in more than one conformational state, which may establish XylE as an important MFS model protein. Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters.,Quistgaard EM, Low C, Moberg P, Tresaugues L, Nordlund P Nat Struct Mol Biol. 2013 Jun;20(6):766-8. doi: 10.1038/nsmb.2569. Epub 2013 Apr , 28. PMID:23624861 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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