4n0n: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n0n RCSB], [http://www.ebi.ac.uk/pdbsum/4n0n PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4n0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4n0n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4n0n RCSB], [http://www.ebi.ac.uk/pdbsum/4n0n PDBsum]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/RPOA_EAVBU RPOA_EAVBU]] The replicase polyprotein 1ab is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.<ref>PMID:18078692</ref> Nsp1 is essential for viral subgenomic mRNA synthesis.<ref>PMID:18078692</ref> Nsp2 cysteine proteinase which cleaves the nsp2/nsp3 site in the polyprotein. Also displays deubiquitinating and deISGylase activities. The deubiquitinating activity cleaves both ubiquitinated and ISGylated products and may therefore regulate ubiquitin and ISG15 dependent host innate immunity.<ref>PMID:18078692</ref> The 3C-like serine proteinase chain is responsible for the majority of cleavages as it cleaves the C-terminus of the polyprotein.<ref>PMID:18078692</ref> The helicase chain, which contains a zinc finger structure, displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity.<ref>PMID:18078692</ref> | |||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
