1blj: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1blj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1blj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1blj RCSB], [http://www.ebi.ac.uk/pdbsum/1blj PDBsum]</span></td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BLK_MOUSE BLK_MOUSE]] Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptor FCGR2. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.<ref>PMID:2404338</ref> <ref>PMID:7690139</ref> <ref>PMID:7608542</ref> <ref>PMID:7592958</ref> <ref>PMID:7565679</ref> <ref>PMID:9177269</ref> <ref>PMID:9636152</ref> <ref>PMID:14662906</ref> <ref>PMID:12563261</ref>

== Evolutionary Conservation ==

[[Image:Consurf_key_small.gif|200px|right]]

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@@ Line 7: / Line 7: @@
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1blj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1blj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1blj RCSB], [http://www.ebi.ac.uk/pdbsum/1blj PDBsum]</span></td></tr>
 </table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BLK_MOUSE BLK_MOUSE]] Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptor FCGR2. With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.<ref>PMID:2404338</ref> <ref>PMID:7690139</ref> <ref>PMID:7608542</ref> <ref>PMID:7592958</ref> <ref>PMID:7565679</ref> <ref>PMID:9177269</ref> <ref>PMID:9636152</ref> <ref>PMID:14662906</ref> <ref>PMID:12563261</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]