Sandbox Reserved 958: Difference between revisions
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'''A'''cquired '''I'''mmune '''D'''efficiency '''S'''yndrome ('''AIDS''') is a human disease caused by the '''H'''uman '''I'''munnodeficiency '''V'''irus ('''HIV''') which is part of the retroviral virus family. This virus infects immune system's cells (Lymphocytes, Macrophages or Dendritic Cells,...) and provoke their destruction by highjacking the cellular machinery. | '''A'''cquired '''I'''mmune '''D'''efficiency '''S'''yndrome ('''AIDS''') is a human disease caused by the '''H'''uman '''I'''munnodeficiency '''V'''irus ('''HIV''') which is part of the retroviral virus family. This virus infects immune system's cells (Lymphocytes, Macrophages or Dendritic Cells,...) and provoke their destruction by highjacking the cellular machinery. | ||
In the first step the virus penetrates the cell through specific membrane receptors then the '''Retrotranscriptase''' transforms the viral RNA into a double strand DNA. Further, it will be integrated into the cellular DNA by association with the integrase and other viral and cellular proteins to form the '''Pre-Integration Complex''' ('''PIC'''). In the last step several viral proteins will be expressed and new virions will be formed by packaging viral and cellular proteins but also the viral RNA. | In the first step the virus penetrates the cell through specific membrane receptors then the '''Retrotranscriptase''' transforms the viral RNA into a double strand DNA. Further, it will be integrated into the cellular DNA by association with the integrase and other viral and cellular proteins to form the '''Pre-Integration Complex''' ('''PIC'''). In the last step several viral proteins will be expressed and new virions will be formed by packaging viral and cellular proteins but also the viral RNA <ref name="Barré-Sinoussi">PMID: 24162027</ref>. | ||
This process leads to an Imunnodeficiency that can indirectly undergo death by an opportunic infection. | This process leads to an Imunnodeficiency that can indirectly undergo death by an opportunic infection. | ||
