Sandbox Reserved 960: Difference between revisions
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=== Cavity === | === Cavity === | ||
The dynamic structure of the protein is responsible of the ligand’s binding by adjustement of position. The structure looses its flexibility when <scene name='60/604479/Cmj/ | The dynamic structure of the protein is responsible of the ligand’s binding by adjustement of position. The structure looses its flexibility when <scene name='60/604479/Cmj/3'>CMJ</scene>binds. The successful delivery of the effector to the receptor relies on this property. The ligand accepting entry of the cavity is formed by H2, H4 and H5 (scene). However, the inside of the cavity is formed by the loop between helixes H3 and H4, and the region from H4 to H5(scene). The cavity is prone to accept such ligand because of its specific composition. Indeed, cavity components are mainly <scene name='60/604479/Hydrophobic_residues/1'>hydrophobic and aromatic</scene> and are localized in the same faces of the helix.Thus, it implies that this residues are regularly distant in the primary structure. | ||
=== Ligands === | === Ligands === | ||
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<scene name='60/604479/Cmj/ | <scene name='60/604479/Cmj/3'>CMJ</scene> | ||
<scene name='60/604479/Cmj_binding_residues/2'>CMJ binding </scene> | <scene name='60/604479/Cmj_binding_residues/2'>CMJ binding </scene> | ||
