1ujl: Difference between revisions

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|ACTIVITY=  
|ACTIVITY=  
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ujl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ujl OCA], [http://www.ebi.ac.uk/pdbsum/1ujl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ujl RCSB]</span>
}}
}}


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==Overview==
==Overview==
The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels.
The HERG K+ channel has very unusual kinetic behaviour that includes slow activation but rapid inactivation. These features are critical for normal cardiac repolarisation as well as in preventing lethal ventricular arrhythmias. Extensive mutagenesis of the HERG K+ channel has allowed identification of which regions of the channel are important for the unusual kinetic behaviour of the channel. Furthermore, structural studies on scorpion toxins that potently inhibit HERG are beginning to provide clues as to the structural differences between HERG and other voltage-gated K+ channels.
==Disease==
Known diseases associated with this structure: Lathosterolosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602286 602286]], Long QT syndrome, acquired, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=152427 152427]], Long QT syndrome-2 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=152427 152427]], Short QT syndrome-1 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=152427 152427]]


==About this Structure==
==About this Structure==
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[[Category: two helice]]
[[Category: two helice]]


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