1uru: Difference between revisions
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|PDB= 1uru |SIZE=350|CAPTION= <scene name='initialview01'>1uru</scene>, resolution 2.60Å | |PDB= 1uru |SIZE=350|CAPTION= <scene name='initialview01'>1uru</scene>, resolution 2.60Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1uru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uru OCA], [http://www.ebi.ac.uk/pdbsum/1uru PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1uru RCSB]</span> | |||
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[[Category: membrane curvature]] | [[Category: membrane curvature]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:14:19 2008'' | ||
Revision as of 21:14, 30 March 2008
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| 1uru, resolution 2.60Å | |||||||||||||
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| Ligands: | MSE | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
AMPHIPHYSIN BAR DOMAIN FROM DROSOPHILA
Overview
The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from yeast to human and is also found in endophilins and nadrins. We solved the structure of the Drosophila amphiphysin BAR domain. It is a crescent-shaped dimer that binds preferentially to highly curved negatively charged membranes. With its N-terminal amphipathic helix and BAR domain (N-BAR), amphiphysin can drive membrane curvature in vitro and in vivo. The structure is similar to that of arfaptin2, which we find also binds and tubulates membranes. From this, we predict that BAR domains are in many protein families, including sorting nexins, centaurins, and oligophrenins. The universal and minimal BAR domain is a dimerization, membrane-binding, and curvature-sensing module.
About this Structure
1URU is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.
Reference
BAR domains as sensors of membrane curvature: the amphiphysin BAR structure., Peter BJ, Kent HM, Mills IG, Vallis Y, Butler PJ, Evans PR, McMahon HT, Science. 2004 Jan 23;303(5657):495-9. Epub 2003 Nov 26. PMID:14645856
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