Sandbox Reserved 960: Difference between revisions
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=== Components implicated in the structure rigidity: === | === Components implicated in the structure rigidity: === | ||
AmelASP1 presents <scene name='60/604479/Disulfide_bonds/1'> three disulfide bridges</scene> which are greatly enhancing its structure’s rigidity by linking four of the helices together.The six cysteines and their interval spacing are the most striking features shared by proteins belonging to the PBP family. | AmelASP1 presents <scene name='60/604479/Disulfide_bonds/1'> three disulfide bridges</scene> which are greatly enhancing its structure’s rigidity by linking four of the helices together. The six cysteines and their interval spacing are the most striking features shared by proteins belonging to the PBP family. | ||
The <scene name='60/604479/1st_disulfide_bridge/1'>first disulfide bridge</scene> is established between <scene name='60/604479/H1/2'>H1</scene> and <scene name='60/604479/H3/2'>H3</scene> through Cysteins 20 and 51. <scene name='60/604479/2nd_disulfide_bridge/2'>An other disulfide bridge</scene> links <scene name='60/604479/H3/2'>H3</scene> and <scene name='60/604479/H6/1'>H6</scene> through Cys 47 and 98, and the <scene name='60/604479/3rd_disulfide_bridge/1'>third disulfide bridge</scene> connects <scene name='60/604479/H5/1'>H5</scene> and <scene name='60/604479/H6/1'>H6</scene> thanks to Cys 89 and Cys 107. | The <scene name='60/604479/1st_disulfide_bridge/1'>first disulfide bridge</scene> is established between <scene name='60/604479/H1/2'>H1</scene> and <scene name='60/604479/H3/2'>H3</scene> through Cysteins 20 and 51. <scene name='60/604479/2nd_disulfide_bridge/2'>An other disulfide bridge</scene> links <scene name='60/604479/H3/2'>H3</scene> and <scene name='60/604479/H6/1'>H6</scene> through Cys 47 and 98, and the <scene name='60/604479/3rd_disulfide_bridge/1'>third disulfide bridge</scene> connects <scene name='60/604479/H5/1'>H5</scene> and <scene name='60/604479/H6/1'>H6</scene> thanks to Cys 89 and Cys 107. | ||
Furthermore, non covalent bonds also play an important role. | Furthermore, non covalent bonds also play an important role. | ||
Indeed, at pH 5.5, Asp 66 and Leu 58 establish an <scene name='60/604479/Hydrogene_bond_1/ | Indeed, at pH 5.5, Asp 66 and Leu 58 establish an <scene name='60/604479/Hydrogene_bond_1/2'>hydrogene bond</scene> which is able to fix a key component structure such as H4. | ||
With their hydrogene bond Val 118 and Ile 119 stabilize alpha helix 2 and C terminal’s position. (scene) | With their hydrogene bond Val 118 and Ile 119 stabilize alpha helix 2 and C terminal’s position. (scene) | ||
