Sandbox Reserved 960: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 27: | Line 27: | ||
===Location in the antenna and transport of pheromones=== | ===Location in the antenna and transport of pheromones=== | ||
ASP1 is a protein which is only produced in the antenna of drones and workers bees. This organ constitutes one major component of the bees’ olfactory system. Cuticules structures of these antennas shelter sensillae which are a gate for pheromones. These sensillae contain neurons. Branched endings are surrounded with sensillar lymph where ASP1 captures 9-ODA and transports it to pheromone receptor in the neuron membrane. PBP’s function is to solubilize | ASP1 is a protein which is only produced in the antenna of drones and workers bees. This organ constitutes one major component of the bees’ olfactory system. Cuticules structures of these antennas shelter sensillae which are a gate for pheromones. These sensillae contain neurons. Branched endings are surrounded with sensillar lymph where ASP1 captures 9-ODA and transports it to pheromone receptor in the neuron membrane. PBP’s function is to solubilize {{Template:ColorKey_Hydrophobic}} odorant molecules, prevent their degradation and to transport them to reach the olfactory receptor. | ||
| Line 61: | Line 61: | ||
pH affects the flexibility of ASP1 because it induces a different protonation state of the <scene name='60/604479/Ionizable_residues/1'>ionizable residues</scene>. Protonated residues induce micro-environnment changes which propagate all along the protein. Consequently, ASP1 is no longer able to interact with its ligands even if ionizable residues are distant from the cavity. | pH affects the flexibility of ASP1 because it induces a different protonation state of the <scene name='60/604479/Ionizable_residues/1'>ionizable residues</scene>. Protonated residues induce micro-environnment changes which propagate all along the protein. Consequently, ASP1 is no longer able to interact with its ligands even if ionizable residues are distant from the cavity. | ||
In fact, depending of the pH level, Asp35 bend the C terminal domain against the cavity. | In fact, depending of the pH level, Asp35 bend the C terminal domain against the cavity. | ||
At pH 5.5, | At pH 5.5, <scene name='60/604479/C-term_asp35/1'>Asp 35</scene> is protonated and C terminal domain isn’t bend against the cavity. While ASP1 is a monomere at acid pH, it can dimerize at neutral and basic pH. | ||
== Ligands == | == Ligands == | ||
