Chaperonin

Crystal Structure of Chaperonin, 1pcq

Chaperonins (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see Chaperonins in Wikipedia.

The most characterized CPN are in the GroEL/GroES complex from Escherichia coli and CPN60/CPN10 from Thermus thermophilus. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya. See also Chaperones.

3D Structures of Chaperonin

Updated on 15-March-2015

{"openlevels":0}

• Group I
• Large subunit
  • 3m6c – MtGroEL1 apical domain – Mycobacterium tuberculosis
    
  • 1sjp, 3rtk – MtGroEL2 residues 42-539
    
  • 3fbh, 2eu1, 1j4z, 1kpo, 1oel, 1grl, 2yey – EcGroEL (mutant) - Escherichia coli
    
  • 3e76, 2nwc, 1xck, 1ss8, 4hel – EcGroEL
    
  • 3c9v, 3cau, 2ynj – EcGroEL – Cryo EM
    
  • 2c7e, 1gr5, 4aaq - EcGroEL (mutant) – Cryo EM
    
  • 1dk7, 1la1 - EcGroEL apical domain
    
  • 1fy9, 1fya, 1kid, 1jon, 3vz6, 3vz7, 3vz8 – EcGroEL apical domain (mutant)
    
  • 1srv – TtCPN60 apical domain - Thermus thermophilus
    
  • 3osx - CPN60 apical domain – Xenorhabdus nematophila
    
  • 1iok – CPN60 – Paracoccus denitrificans
• Large subunit binary complex
  • 1kp8 - EcGroEL (mutant) + ATP
    
  • 4aar, 4aas, 4aau, 4ab2, 4ab3 - EcGroEL (mutant) + ATP – Cryo EM
    
  • 1sx3 - EcGroEL + ATP
    
  • 1sx4 - EcGroEL + ADP
    
  • 4ki8 - EcGroEL (mutant) + ADP
    
  • 1mnf – EcGroEL + polypeptide
    
  • 2cgt – EcGroEL + capsid assbly protein GP31 – EM
    
  • 1dkd - EcGroEL apical domain + polypeptide
• Small subunit
  • 3nx6 – GroES residues 40-134 (mutant) – Xanthomonas oryzae
    
  • 1wnr – TtCPN10 residues 1-94
    
  • 1p3h, 1hx5 – MtCPN10
    
  • 1p82, 1p83 - MtCPN10 residues 1-25 - NMR
    
  • 1egs - GroES residues 19-27 - NMR
• Large + small subunit
  • 1svt, 1pcq - EcGroEL + GroES
    
  • 1pf9, 1aon, 4pko - EcGroEL + GroES + ADP
    
  • 3wvl - EcGroEL (mutant) + GroES + ATP
    
  • 2c7c, 2c7d - EcGroEL + GroES – Cryo EM
    
  • 1gru - EcGroEL + GroES + ATP + ADP – Cryo EM
    
  • 3zpz, 3zq0, 3zq1 - EcGroEL + GroES + ADP – Cryo EM
    
  • 1we3 – TtCPN60 + CPN10
    
  • 1wf4, 4v4o, 4pkn - TtCPN60 + CPN10 + ADP
• Group II
  • 3izh, 3izi, 3izj, 3izk, 3izl, 3izm, 3izn, 3los, 3iyf, 3j3x – MmCPN – Methanococcus maripaludis – EM
    
  • 3kfb, 3kfe, 3kfk – MmCPN
    
  • 3j02, 3j03 – MmCPN (mutant) – Cryo EM
    
  • 3ruq - MmCPN + ADP
    
  • 3rus - MmCPN (mutant) + ADP
    
  • 3ruw - MmCPN (mutant) + ADP-AlF3
    
  • 3ruv - MmCPN (mutant) + ATP analog
    
• CCT
  • 2xsm, 4b2t – bCPN CCT – bovine
    
  • 3p9d, 3p9e, 4d8q, 4d8r, 4aol, 4apk – CPN CCT - yeast
    
  • 3iyg, 4a0o - bCPN CCT – Cryo EM
    
  • 4a0v - bCPN CCT + AMPPNP – Cryo EM
    
  • 4a0w - bCPN CCT + ADP + AlF3 – Cryo EM
    
  • 4a13 - bCPN CCT + ADP – Cryo EM
    
  • 3ktt - bCPN CCT β subunit – Cryo EM
    
  • 1gml, 1gn1 - CPN CCT γ subunit apical domain – mouse
• Hsp33

See Heat Shock Proteins

• Thermosome
  • 1a6d - TaTherm α+β subunits – Thermoplasma acidophilum
    
  • 1a6e - TaTherm α+β subunits + ADP
    
  • 1ass, 1asx - TaTherm α apical domain
    
  • 1e0r – TaTherm β apical domain
    
  • 3ko1 – AtTherm α subunit– Acidianus tengchongensis
    
  • 3j1b, 3j1c, 3j1e - AtTherm α subunit – Cryo EM
    
  • 3j1f - AtTherm β subunit + ATP – Cryo EM
    
  • 3aq1 – Therm – Methanococcoides burtonii
    
  • 1q2v, 1q3r – TkTherm α subunit (mutant) – Thermococcus KS-1
    
  • 1q3q - TkTherm α subunit (mutant) + AMP-PNP
    
  • 1q3s - TkTherm α subunit (mutant) + ADP
    
  • 1lep – CPN-10 – Mycobacterium leprae

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Eric Martz, Joel L. Sussman