2mp1: Difference between revisions

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'''Unreleased structure'''
==Solution structure of the human chemokine CCL19==
 
<StructureSection load='2mp1' size='340' side='right' caption='[[2mp1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
The entry 2mp1 is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[2mp1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MP1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MP1 FirstGlance]. <br>
Authors: Veldkamp, C.T., Peterson, F.C., Gabel-Eissens, S.J., Gillitzer, M.L.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mp1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mp1 RCSB], [http://www.ebi.ac.uk/pdbsum/2mp1 PDBsum]</span></td></tr>
 
</table>
Description: Solution structure of the human chemokine CCL19
== Function ==
[[Category: Unreleased Structures]]
[[http://www.uniprot.org/uniprot/CCL19_HUMAN CCL19_HUMAN]] May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4.<ref>PMID:9498785</ref> 
[[Category: Gabel-Eissens, S.J]]
== References ==
[[Category: Peterson, F.C]]
<references/>
[[Category: Gillitzer, M.L]]
__TOC__
[[Category: Veldkamp, C.T]]
</StructureSection>
[[Category: Gabel-Eissens, S J]]
[[Category: Gillitzer, M L]]
[[Category: Peterson, F C]]
[[Category: Veldkamp, C T]]
[[Category: Ccl19]]
[[Category: Ccl21]]
[[Category: Ccr7]]
[[Category: Chemokine receptor]]
[[Category: Chemokine]]
[[Category: Signaling protein]]
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