4d2g: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human PCNA in complex with p15 peptide==
 
<StructureSection load='4d2g' size='340' side='right' caption='[[4d2g]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
The entry 4d2g is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4d2g]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D2G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4D2G FirstGlance]. <br>
Authors: DeBiasio, A., Ibanez, A., Mortuza, G., Molina, R., Cordeiro, T.N., Castillo, F., Villate, M., Merino, N., Lelli, M., Diercks, T., Luque, I., Bernardo, P., Montoya, G., Blanco, F.J.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4d2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d2g OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4d2g RCSB], [http://www.ebi.ac.uk/pdbsum/4d2g PDBsum]</span></td></tr>
 
</table>
Description: Crystal structure of human PCNA in complex with p15 peptide
== Function ==
[[Category: Unreleased Structures]]
[[http://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN]] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bernardo, P]]
[[Category: Blanco, F J]]
[[Category: Castillo, F]]
[[Category: Cordeiro, T N]]
[[Category: DeBiasio, A]]
[[Category: Diercks, T]]
[[Category: Ibanez, A]]
[[Category: Ibanez, A]]
[[Category: Lelli, M]]
[[Category: Lelli, M]]
[[Category: Castillo, F]]
[[Category: Luque, I]]
[[Category: Bernardo, P]]
[[Category: Merino, N]]
[[Category: Diercks, T]]
[[Category: Molina, R]]
[[Category: Molina, R]]
[[Category: Merino, N]]
[[Category: Montoya, G]]
[[Category: Blanco, F.J]]
[[Category: Mortuza, G]]
[[Category: Luque, I]]
[[Category: Debiasio, A]]
[[Category: Cordeiro, T.N]]
[[Category: Villate, M]]
[[Category: Villate, M]]
[[Category: Mortuza, G]]
[[Category: Transcription]]
[[Category: Montoya, G]]
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