4nnl: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to F-iCAL36 (ANSRFPTSII) peptide==

~~The entry~~ 4nnl is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4nnl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NNL FirstGlance]. <br>

~~Authors~~: ~~Amacher~~, J.F., ~~Madden~~, D.R.

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sfj|3sfj]], [[4nnm|4nnm]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nnl RCSB], [http://www.ebi.ac.uk/pdbsum/4nnl PDBsum]</span></td></tr>

~~Description~~: ~~Tax~~-~~Interacting Protein-1 (TIP-1)~~ PDZ domain ~~bound to~~ F-~~iCAL36 (ANSRFPTSII)~~ peptide

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[Category: ~~Amacher, J.F~~]]

[[http://www.uniprot.org/uniprot/TX1B3_HUMAN TX1B3_HUMAN]] May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.<ref>PMID:10940294</ref> <ref>PMID:16855024</ref> <ref>PMID:21139582</ref>

[[Category: ~~Madden, D.R~~]]

== References ==

__TOC__

</StructureSection>

[[Category: Amacher, J F]]

[[Category: Madden, D R]]

[[Category: Pdz]]

[[Category: Pdz-peptide]]

[[Category: Protein binding]]

[[Category: Tax-interacting protein-1]]

[[Category: Tip-1]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to F-iCAL36 (ANSRFPTSII) peptide==
+<StructureSection load='4nnl' size='340' side='right' caption='[[4nnl]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
-The entry 4nnl is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4nnl]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4NNL FirstGlance]. <br>
-Authors: Amacher, J.F., Madden, D.R.
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sfj|3sfj]], [[4nnm|4nnm]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4nnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4nnl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4nnl RCSB], [http://www.ebi.ac.uk/pdbsum/4nnl PDBsum]</span></td></tr>
-Description: Tax-Interacting Protein-1 (TIP-1) PDZ domain bound to F-iCAL36 (ANSRFPTSII) peptide
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Amacher, J.F]]
+[[http://www.uniprot.org/uniprot/TX1B3_HUMAN TX1B3_HUMAN]] May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. Binds CTNNB1 and may thereby act as an inhibitor of the Wnt signaling pathway. Competes with LIN7A for KCNJ4 binding, and thereby promotes KCNJ4 internalization. May play a role in the Rho signaling pathway. May play a role in activation of CDC42 by the viral protein HPV16 E6.<ref>PMID:10940294</ref> <ref>PMID:16855024</ref> <ref>PMID:21139582</ref>
-[[Category: Madden, D.R]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Amacher, J F]]
+[[Category: Madden, D R]]
+[[Category: Pdz]]
+[[Category: Pdz-peptide]]
+[[Category: Protein binding]]
+[[Category: Tax-interacting protein-1]]
+[[Category: Tip-1]]