4oeo: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==High resolution crystal structure of the unliganded ZO-1 PDZ1 domain==

~~The entry~~ 4oeo is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4oeo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OEO OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OEO FirstGlance].

~~Authors~~: ~~Nomme~~, J., ~~Lavie~~, A.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4oep|4oep]], [[4oeq|4oeq]]</td></tr>

~~Description: High resolution crystal structure of the unliganded ZO-1 PDZ1 domain~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oeo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oeo RCSB], [http://www.ebi.ac.uk/pdbsum/4oeo PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Lavie, A]]

[[Category: Nomme, J]]

[[Category: Cell adhesion]]

[[Category: Claudin]]

[[Category: Maguk]]

[[Category: Pdz1]]

[[Category: Scaffolding]]

[[Category: Tight junction assembly]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==High resolution crystal structure of the unliganded ZO-1 PDZ1 domain==
+<StructureSection load='4oeo' size='340' side='right' caption='[[4oeo]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-The entry 4oeo is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4oeo]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4OEO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4OEO FirstGlance]. <br>
-Authors: Nomme, J., Lavie, A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=12P:DODECAETHYLENE+GLYCOL'>12P</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4oep|4oep]], [[4oeq|4oeq]]</td></tr>
-Description: High resolution crystal structure of the unliganded ZO-1 PDZ1 domain
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oeo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oeo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oeo RCSB], [http://www.ebi.ac.uk/pdbsum/4oeo PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN]] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Lavie, A]]
 [[Category: Nomme, J]]
+[[Category: Cell adhesion]]
+[[Category: Claudin]]
+[[Category: Maguk]]
+[[Category: Pdz1]]
+[[Category: Scaffolding]]
+[[Category: Tight junction assembly]]