4ph5: Difference between revisions
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==Structure of human DNA polymerase btea complexed with a nicked DNA containing a AC at N-1 position and GC at N position== | |||
<StructureSection load='4ph5' size='340' side='right' caption='[[4ph5]], [[Resolution|resolution]] 2.55Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ph5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PH5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PH5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ph5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ph5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ph5 RCSB], [http://www.ebi.ac.uk/pdbsum/4ph5 PDBsum]</span></td></tr> | |||
</table> | |||
[[ | == Function == | ||
[[Category: Koag, M | [[http://www.uniprot.org/uniprot/DPOLB_HUMAN DPOLB_HUMAN]] Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.<ref>PMID:9207062</ref> <ref>PMID:9572863</ref> <ref>PMID:11805079</ref> <ref>PMID:21362556</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Koag, M C]] | |||
[[Category: Lee, S]] | [[Category: Lee, S]] | ||
[[Category: Human dna polymerase beta]] | |||
[[Category: Nucleotidyl trnasfer]] | |||
Revision as of 12:57, 6 May 2015
Structure of human DNA polymerase btea complexed with a nicked DNA containing a AC at N-1 position and GC at N position
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