4puw: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

==Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A==

~~The entry 4puw is ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4puw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUW OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUW FirstGlance].

~~Authors: Rechlin, C., Heine, A., Klebe, G.~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2WQ:[5-FLUORO-2-(PROP-2-YN-1-YLCARBAMOYL)PHENOXY]ACETIC+ACID'>2WQ</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[1us0|1us0]], [[2ikj|2ikj]], [[4puu|4puu]]</td></tr>

~~Description:~~ Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4puw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4puw RCSB], [http://www.ebi.ac.uk/pdbsum/4puw PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

__TOC__

</StructureSection>

[[Category: Aldehyde reductase]]

[[Category: Heine, A]]

[[Category: Klebe, G]]

[[Category: Rechlin, C]]

[[Category: ~~Klebe, G~~]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

[[Category: Tim barrel]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A==
+<StructureSection load='4puw' size='340' side='right' caption='[[4puw]], [[Resolution|resolution]] 1.12&Aring;' scene=''>
-The entry 4puw is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4puw]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PUW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PUW FirstGlance]. <br>
-Authors: Rechlin, C., Heine, A., Klebe, G.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WQ:[5-FLUORO-2-(PROP-2-YN-1-YLCARBAMOYL)PHENOXY]ACETIC+ACID'>2WQ</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1us0|1us0]], [[2ikj|2ikj]], [[4puu|4puu]]</td></tr>
-Description: Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Aldehyde_reductase Aldehyde reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.21 1.1.1.21] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4puw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4puw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4puw RCSB], [http://www.ebi.ac.uk/pdbsum/4puw PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/ALDR_HUMAN ALDR_HUMAN]] Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
+__TOC__
+</StructureSection>
+[[Category: Aldehyde reductase]]
 [[Category: Heine, A]]
+[[Category: Klebe, G]]
 [[Category: Rechlin, C]]
-[[Category: Klebe, G]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
+[[Category: Tim barrel]]