4px5: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate==

~~The entry~~ 4px5 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4px5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PX5 FirstGlance]. <br>

~~Authors~~: ~~Jordan~~, S.R., ~~Chmait~~, S.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WZ:N-[(R)-(2-AMINO-5-CHLORO-3-FLUOROPYRIDIN-4-YL){7-[4-(2-HYDROXYPROPAN-2-YL)PYRIDIN-2-YL]-1-BENZOTHIOPHEN-2-YL}METHYL]CYCLOPROPANESULFONAMIDE'>2WZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4px5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4px5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4px5 RCSB], [http://www.ebi.ac.uk/pdbsum/4px5 PDBsum]</span></td></tr>

~~Description: Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate~~

</table>

[[~~Category~~: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.

__TOC__

</StructureSection>

[[Category: Chmait, S]]

[[Category: Jordan, S.R]]

[[Category: Jordan, S R]]

[[Category: Glucokinase]]

[[Category: Regulatory protein - binds to and inhibits glucokinase]]

[[Category: Sis domain containing protein]]

[[Category: Sugar binding protein-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate==
+<StructureSection load='4px5' size='340' side='right' caption='[[4px5]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-The entry 4px5 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4px5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PX5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PX5 FirstGlance]. <br>
-Authors: Jordan, S.R., Chmait, S.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2WZ:N-[(R)-(2-AMINO-5-CHLORO-3-FLUOROPYRIDIN-4-YL){7-[4-(2-HYDROXYPROPAN-2-YL)PYRIDIN-2-YL]-1-BENZOTHIOPHEN-2-YL}METHYL]CYCLOPROPANESULFONAMIDE'>2WZ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=S6P:D-SORBITOL-6-PHOSPHATE'>S6P</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4px5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4px5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4px5 RCSB], [http://www.ebi.ac.uk/pdbsum/4px5 PDBsum]</span></td></tr>
-Description: Human GKRP bound to AMG-0696 and Sorbitol-6-phosphate
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/GCKR_HUMAN GCKR_HUMAN]] Inhibits glucokinase by forming an inactive complex with this enzyme.
+__TOC__
+</StructureSection>
 [[Category: Chmait, S]]
-[[Category: Jordan, S.R]]
+[[Category: Jordan, S R]]
+[[Category: Glucokinase]]
+[[Category: Regulatory protein - binds to and inhibits glucokinase]]
+[[Category: Sis domain containing protein]]
+[[Category: Sugar binding protein-inhibitor complex]]