1xp1: Difference between revisions

Line 7:

|ACTIVITY=

|GENE= ESR1, NR3A1, ESR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])

|DOMAIN=

|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xp1 OCA], [http://www.ebi.ac.uk/pdbsum/1xp1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xp1 RCSB]</span>

}}

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==Overview==

A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.

~~==Disease==~~

Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Estrogen resistance OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], HDL response to hormone replacement, augmented OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Migraine, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]]

==About this Structure==

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[[Category: Fitzgerald, P M.D.]]

[[Category: Sharma, N.]]

~~[[Category: AIH]]~~

[[Category: antagonist]]

[[Category: er-alpha]]

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[[Category: transcription factor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Thu~~ Mar ~~20 15~~:12:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:38 2008''

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@@ Line 7: / Line 7: @@
 |ACTIVITY=
 |GENE= ESR1, NR3A1, ESR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+|DOMAIN=
+|RELATEDENTRY=[[1sj0|1SJ0]], [[1xp6|1XP6]], [[1xp9|1XP9]], [[1xpc|1XPC]]
+|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xp1 OCA], [http://www.ebi.ac.uk/pdbsum/1xp1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xp1 RCSB]</span>
 }}
@@ Line 14: / Line 17: @@
 ==Overview==
 A series of dihydrobenzoxathiin SERAMs with alkylated pyrrolidine side chains or alkylated linkers was prepared. Minor modifications in the side chain or linker resulted in significant effects on biological activity, especially in uterine tissue.
-==Disease==
-Known diseases associated with this structure: Atherosclerosis, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Breast cancer OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Estrogen resistance OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], HDL response to hormone replacement, augmented OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Migraine, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]], Myocardial infarction, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=133430 133430]]
 ==About this Structure==
@@ Line 27: / Line 27: @@
 [[Category: Fitzgerald, P M.D.]]
 [[Category: Sharma, N.]]
-[[Category: AIH]]
 [[Category: antagonist]]
 [[Category: er-alpha]]
@@ Line 33: / Line 32: @@
 [[Category: transcription factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:12:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:38 2008''