1xuo: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 1xuo |SIZE=350|CAPTION= <scene name='initialview01'>1xuo</scene>, resolution 1.80Å | |PDB= 1xuo |SIZE=350|CAPTION= <scene name='initialview01'>1xuo</scene>, resolution 1.80Å | ||
|SITE= | |SITE= | ||
|LIGAND= | |LIGAND= <scene name='pdbligand=LA1:(2R)-2-[3-ISOBUTYL-2,5-DIOXO-4-(QUINOLIN-3-YLMETHYL)-1,4-DIAZEPAN-1-YL]-N-METHYL-3-(2-NAPHTHYL)PROPANAMIDE'>LA1</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1xdd|1XDD]], [[1xdg|1XDG]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xuo OCA], [http://www.ebi.ac.uk/pdbsum/1xuo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xuo RCSB]</span> | |||
}} | }} | ||
| Line 32: | Line 35: | ||
[[Category: Weckbecker, G.]] | [[Category: Weckbecker, G.]] | ||
[[Category: Welzenbach, K.]] | [[Category: Welzenbach, K.]] | ||
[[Category: i-domain]] | [[Category: i-domain]] | ||
[[Category: integrin]] | [[Category: integrin]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:52 2008'' | ||
Revision as of 21:54, 30 March 2008
| |||||||||||||
| 1xuo, resolution 1.80Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | LA1, MG | ||||||||||||
| Related: | 1XDD, 1XDG
| ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
X-ray structure of LFA-1 I-domain bound to a 1,4-diazepane-2,5-dione inhibitor at 1.8A resolution
Overview
1,4-Diazepane-2,5-diones (2) are found to be a new class of potent LFA-1 inhibitors. The synthesis, structure, and biological evaluation of these 1,4-diazepine-2,5-diones and related derivatives are described.
About this Structure
1XUO is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1., Wattanasin S, Kallen J, Myers S, Guo Q, Sabio M, Ehrhardt C, Albert R, Hommel U, Weckbecker G, Welzenbach K, Weitz-Schmidt G, Bioorg Med Chem Lett. 2005 Feb 15;15(4):1217-20. PMID:15686945
Page seeded by OCA on Mon Mar 31 00:54:52 2008
