4r09: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of human TLR8 in complex with ORN06S==

~~The entry~~ 4r09 is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4r09]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R09 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R09 FirstGlance].

~~Authors~~: ~~Tanji~~, H., ~~Ohto~~, U., ~~Shimizu~~, T.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=06S:O-[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-3,6-DIHYDRO-9H-PURIN-9-YL)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-HYDROXY-2-[(THIOPHOSPHONOOXY)METHYL]TETRAHYDROFURAN-3-YL}OXY)(SULFANYL)PHOSPHORYL]OXY}METHYL)-4-HYDROXYTETRAHYDROFURAN-3-YL]+DIHYDROGEN+(S)-PHOSPHOROTHIOATE'>06S</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPT:1-[(2R,3AR,4R,6R,6AR)-2-HYDROXY-6-(HYDROXYMETHYL)-2-SULFIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]PYRIMIDINE-2,4(1H,3H)-DIONE'>UPT</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4r07|4r07]], [[4r08|4r08]], [[4r0a|4r0a]]</td></tr>

~~Description~~: ~~Crystal structure of human TLR8 in complex with ORN06S~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r09 RCSB], [http://www.ebi.ac.uk/pdbsum/4r09 PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[~~Category~~: ~~Tanji, H~~]]

== Function ==

[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Ohto, U]]

[[Category: Shimizu, T]]

[[Category: Tanji, H]]

[[Category: Antitumor drug binding]]

[[Category: Antiviral binding]]

[[Category: Glycosylation]]

[[Category: Immune system]]

[[Category: Innate immunity]]

[[Category: Leucine rich repeat]]

[[Category: Rna]]

[[Category: Rna binding]]

[[Category: Rna receptor]]

[[Category: Rna recognition]]

[[Category: Ssrna]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human TLR8 in complex with ORN06S==
+<StructureSection load='4r09' size='340' side='right' caption='[[4r09]], [[Resolution|resolution]] 2.62&Aring;' scene=''>
-The entry 4r09 is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4r09]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R09 FirstGlance]. <br>
-Authors: Tanji, H., Ohto, U., Shimizu, T.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=06S:O-[(2R,3S,4R,5R)-5-(2-AMINO-6-OXO-3,6-DIHYDRO-9H-PURIN-9-YL)-2-({[(S)-({(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-4-HYDROXY-2-[(THIOPHOSPHONOOXY)METHYL]TETRAHYDROFURAN-3-YL}OXY)(SULFANYL)PHOSPHORYL]OXY}METHYL)-4-HYDROXYTETRAHYDROFURAN-3-YL]+DIHYDROGEN+(S)-PHOSPHOROTHIOATE'>06S</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=UPT:1-[(2R,3AR,4R,6R,6AR)-2-HYDROXY-6-(HYDROXYMETHYL)-2-SULFIDOTETRAHYDROFURO[3,4-D][1,3,2]DIOXAPHOSPHOL-4-YL]PYRIMIDINE-2,4(1H,3H)-DIONE'>UPT</scene>, <scene name='pdbligand=URI:URIDINE'>URI</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r07|4r07]], [[4r08|4r08]], [[4r0a|4r0a]]</td></tr>
-Description: Crystal structure of human TLR8 in complex with ORN06S
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r09 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r09 RCSB], [http://www.ebi.ac.uk/pdbsum/4r09 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Tanji, H]]
+== Function ==
+[[http://www.uniprot.org/uniprot/TLR8_HUMAN TLR8_HUMAN]] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.<ref>PMID:17932028</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Ohto, U]]
 [[Category: Shimizu, T]]
+[[Category: Tanji, H]]
+[[Category: Antitumor drug binding]]
+[[Category: Antiviral binding]]
+[[Category: Glycosylation]]
+[[Category: Immune system]]
+[[Category: Innate immunity]]
+[[Category: Leucine rich repeat]]
+[[Category: Rna]]
+[[Category: Rna binding]]
+[[Category: Rna receptor]]
+[[Category: Rna recognition]]
+[[Category: Ssrna]]