4r7a: Difference between revisions
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''' | ==Crystal Structure of RBBP4 bound to PHF6 peptide== | ||
<StructureSection load='4r7a' size='340' side='right' caption='[[4r7a]], [[Resolution|resolution]] 1.85Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4r7a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R7A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R7A FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r7a OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r7a RCSB], [http://www.ebi.ac.uk/pdbsum/4r7a PDBsum]</span></td></tr> | |||
</table> | |||
[[ | == Disease == | ||
[[Category: | [[http://www.uniprot.org/uniprot/PHF6_HUMAN PHF6_HUMAN]] Borjeson-Forssman-Lehmann syndrome. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PHF6_HUMAN PHF6_HUMAN]] Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription.<ref>PMID:23229552</ref> [[http://www.uniprot.org/uniprot/RBBP4_HUMAN RBBP4_HUMAN]] Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.<ref>PMID:10866654</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Li, F]] | |||
[[Category: Li, S]] | [[Category: Li, S]] | ||
[[Category: Liu, Z]] | [[Category: Liu, Z]] | ||
[[Category: Shi, Y]] | [[Category: Shi, Y]] | ||
[[Category: Wu, J]] | |||
[[Category: Zhang, B]] | |||
[[Category: Gene regulation]] | |||
[[Category: Nuclear]] | |||
[[Category: Wd40 repeat domain]] | |||
Revision as of 13:44, 14 January 2015
Crystal Structure of RBBP4 bound to PHF6 peptide
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