4rah: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.4 Angstrom resolution==

~~The entry~~ 4rah is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4rah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAH FirstGlance]. <br>

~~Authors~~: ~~Halabelian~~, L., ~~Bolognesi~~, M., ~~Ricagno, S~~.

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r9h|4r9h]], [[4ra3|4ra3]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rah OCA], [http://pdbe.org/4rah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rah RCSB], [http://www.ebi.ac.uk/pdbsum/4rah PDBsum]</span></td></tr>

~~Description~~: ~~Crystal structure~~ of ~~dimeric S33C~~ beta-2 microglobulin ~~mutant at 1~~.~~4 Angstrom resolution~~

</table>

[[Category: ~~Unreleased Structures~~]]

== Disease ==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>

== Function ==

[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

== References ==

__TOC__

</StructureSection>

[[Category: Bolognesi, M]]

[[Category: Halabelian, L]]

[[Category: Ricagno, S]]

[[Category: ~~Bolognesi, M~~]]

[[Category: Amyloidosis]]

[[Category: Beta sandwich]]

[[Category: Covalent dimer]]

[[Category: Immune system]]

[[Category: Inclusion body]]

[[Category: Oligomerization]]

[[Category: Protein aggregation]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.4 Angstrom resolution==
+<StructureSection load='4rah' size='340' side='right' caption='[[4rah]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
-The entry 4rah is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rah]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RAH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RAH FirstGlance]. <br>
-Authors: Halabelian, L., Bolognesi, M., Ricagno, S.
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r9h|4r9h]], [[4ra3|4ra3]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rah OCA], [http://pdbe.org/4rah PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rah RCSB], [http://www.ebi.ac.uk/pdbsum/4rah PDBsum]</span></td></tr>
-Description: Crystal structure of dimeric S33C beta-2 microglobulin mutant at 1.4 Angstrom resolution
+</table>
-[[Category: Unreleased Structures]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref>   Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Bolognesi, M]]
 [[Category: Halabelian, L]]
 [[Category: Ricagno, S]]
-[[Category: Bolognesi, M]]
+[[Category: Amyloidosis]]
+[[Category: Beta sandwich]]
+[[Category: Covalent dimer]]
+[[Category: Immune system]]
+[[Category: Inclusion body]]
+[[Category: Oligomerization]]
+[[Category: Protein aggregation]]