4re9: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290==

~~The entry~~ 4re9 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4re9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RE9 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RE9 FirstGlance].

~~Authors~~: ~~Liang~~, W.G., ~~Deprez~~, R., ~~Deprez~~, B.~~, Tang, W~~.J.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=3M9:4-FLUORO-N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2-YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-5-YL}METHYL)BENZAMIDE'>3M9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </td></tr>

~~Description~~: ~~Crystal structure~~ of ~~human~~ insulin ~~degrading enzyme (IDE)~~ in ~~complex with compound 71290~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4re9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4re9 OCA], [http://pdbe.org/4re9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4re9 RCSB], [http://www.ebi.ac.uk/pdbsum/4re9 PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Insulysin]]

[[Category: Deprez, B]]

[[Category: Deprez, R]]

[[Category: Liang, W.G]]

[[Category: Liang, W G]]

[[Category: Tang, W.J]]

[[Category: Tang, W J]]

[[Category: ~~Deprez, B~~]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

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-'''Unreleased structure'''
+==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290==
+<StructureSection load='4re9' size='340' side='right' caption='[[4re9]], [[Resolution|resolution]] 2.91&Aring;' scene=''>
-The entry 4re9 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4re9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RE9 FirstGlance]. <br>
-Authors: Liang, W.G., Deprez, R., Deprez, B., Tang, W.J.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=3M9:4-FLUORO-N-({1-[(2R)-4-(HYDROXYAMINO)-1-(NAPHTHALEN-2-YL)-4-OXOBUTAN-2-YL]-1H-1,2,3-TRIAZOL-5-YL}METHYL)BENZAMIDE'>3M9</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Insulysin Insulysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.56 3.4.24.56] </span></td></tr>
-Description: Crystal structure of human insulin degrading enzyme (IDE) in complex with compound 71290
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4re9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4re9 OCA], [http://pdbe.org/4re9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4re9 RCSB], [http://www.ebi.ac.uk/pdbsum/4re9 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Insulysin]]
+[[Category: Deprez, B]]
 [[Category: Deprez, R]]
-[[Category: Liang, W.G]]
+[[Category: Liang, W G]]
-[[Category: Tang, W.J]]
+[[Category: Tang, W J]]
-[[Category: Deprez, B]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]