4rsz: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==The X-ray structure of the Primary Adduct formed in the Reaction between Cisplatin and Cytochrome c==

~~The entry~~ 4rsz is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4rsz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RSZ FirstGlance]. <br>

~~Authors~~: ~~Merlino~~, A.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rsz RCSB], [http://www.ebi.ac.uk/pdbsum/4rsz PDBsum]</span></td></tr>

~~Description~~: The X-~~ray structure~~ of the ~~Primary Adduct formed~~ in the ~~Reaction between Cisplatin and Cytochrome~~ c

</table>

[[Category: ~~Unreleased Structures~~]]

== Function ==

[[http://www.uniprot.org/uniprot/CYC_HORSE CYC_HORSE]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).

__TOC__

</StructureSection>

[[Category: Equus caballus]]

[[Category: Merlino, A]]

[[Category: Electron transport]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The X-ray structure of the Primary Adduct formed in the Reaction between Cisplatin and Cytochrome c==
+<StructureSection load='4rsz' size='340' side='right' caption='[[4rsz]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
-The entry 4rsz is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rsz]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Equus_caballus Equus caballus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RSZ FirstGlance]. <br>
-Authors: Merlino, A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rsz RCSB], [http://www.ebi.ac.uk/pdbsum/4rsz PDBsum]</span></td></tr>
-Description: The X-ray structure of the Primary Adduct formed in the Reaction between Cisplatin and Cytochrome c
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
+[[http://www.uniprot.org/uniprot/CYC_HORSE CYC_HORSE]] Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.  Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Equus caballus]]
 [[Category: Merlino, A]]
+[[Category: Electron transport]]