4rut: Difference between revisions
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''' | ==crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid== | ||
<StructureSection load='4rut' size='340' side='right' caption='[[4rut]], [[Resolution|resolution]] 2.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4rut]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RUT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RUT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=LM8:(5Z,8Z,11Z,13S,14Z)-13-METHYLICOSA-5,8,11,14-TETRAENOIC+ACID'>LM8</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rut OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rut RCSB], [http://www.ebi.ac.uk/pdbsum/4rut PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/PGH2_MOUSE PGH2_MOUSE]] Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.<ref>PMID:12925531</ref> <ref>PMID:20463020</ref> <ref>PMID:20810665</ref> <ref>PMID:21489986</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Prostaglandin-endoperoxide synthase]] | |||
[[Category: Banerjee, S]] | |||
[[Category: Kudalkar, S N]] | |||
[[Category: Makriyannis, A]] | [[Category: Makriyannis, A]] | ||
[[Category: Nikas, S | [[Category: Marnett, L J]] | ||
[[Category: Nikas, S P]] | |||
[[Category: Xu, S]] | [[Category: Xu, S]] | ||
[[Category: | [[Category: Fatty acid analog]] | ||
[[Category: | [[Category: Glycosylation]] | ||
[[Category: | [[Category: Membrane]] | ||
[[Category: Oxidoreductase]] | |||
[[Category: Protein-ligand complex]] | |||
Revision as of 11:59, 12 February 2015
crystal structure of murine cyclooxygenase-2 with 13-methyl-arachidonic Acid
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