4rv3: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus==

~~The entry~~ 4rv3 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV3 FirstGlance].

~~Authors~~: He, T., ~~Gershenson~~, A., ~~Eyles~~, S.J., ~~Gao~~, J.~~, Roberts, M~~.F.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>

~~Description~~: ~~Crystal structure of a pentafluoro-Phe incorporated~~ Phosphatidylinositol-~~specific phospholipase C (H258X)from~~ Staphylococcus aureus

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[3v16|3v16]]</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv3 PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.

__TOC__

</StructureSection>

[[Category: Phosphatidylinositol diacylglycerol-lyase]]

[[Category: Staphylococcus aureus]]

[[Category: Eyles, S J]]

[[Category: Gao, J]]

[[Category: Gershenson, A]]

~~[[Category: Roberts, M.F]]~~

~~[[Category: Eyles, S.J]]~~

[[Category: He, T]]

[[Category: ~~Gao~~, J]]

[[Category: Roberts, M F]]

[[Category: Cation-pi]]

[[Category: Encoded unnatural amino acid phospholipase]]

[[Category: Lyase]]

[[Category: Tim barrel]]

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-'''Unreleased structure'''
+==Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus==
+<StructureSection load='4rv3' size='340' side='right' caption='[[4rv3]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-The entry 4rv3 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rv3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RV3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RV3 FirstGlance]. <br>
-Authors: He, T., Gershenson, A., Eyles, S.J., Gao, J., Roberts, M.F.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=INS:1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE'>INS</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PF5:2,3,4,5,6-PENTAFLUORO-L-PHENYLALANINE'>PF5</scene></td></tr>
-Description: Crystal structure of a pentafluoro-Phe incorporated Phosphatidylinositol-specific phospholipase C (H258X)from Staphylococcus aureus
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3v16|3v16]]</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_diacylglycerol-lyase Phosphatidylinositol diacylglycerol-lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.13 4.6.1.13] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rv3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rv3 RCSB], [http://www.ebi.ac.uk/pdbsum/4rv3 PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/PLC_STAAE PLC_STAAE]] Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Potential virulence factor.
+__TOC__
+</StructureSection>
+[[Category: Phosphatidylinositol diacylglycerol-lyase]]
+[[Category: Staphylococcus aureus]]
+[[Category: Eyles, S J]]
+[[Category: Gao, J]]
 [[Category: Gershenson, A]]
-[[Category: Roberts, M.F]]
-[[Category: Eyles, S.J]]
 [[Category: He, T]]
-[[Category: Gao, J]]
+[[Category: Roberts, M F]]
+[[Category: Cation-pi]]
+[[Category: Encoded unnatural amino acid phospholipase]]
+[[Category: Lyase]]
+[[Category: Tim barrel]]