4rwv: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of PIP3 bound human nuclear receptor LRH-1 (Liver Receptor Homolog 1, NR5A2) in complex with a co-regulator DAX-1 (NR0B1) peptide at 1.86 A resolution==
 
<StructureSection load='4rwv' size='340' side='right' caption='[[4rwv]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
The entry 4rwv is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4rwv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RWV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RWV FirstGlance]. <br>
Authors: Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology, Partnership for Stem Cell Biology (STEMCELL)
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PIZ:(2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-DIHYDROXY-3,4,5-TRIS(PHOSPHONOOXY)CYCLOHEXYL]OXY}(HYDROXY)PHOSPHORYL]OXY}PROPANE-1,2-DIYL+DIHEXADECANOATE'>PIZ</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
 
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
Description: Crystal structure of a Homo sapiens hepatocytic transcription factor hB1F-2 (B1F2) in complex with nuclear receptor subfamily 0 group B member 1 (NR0B1, residues 140-154) from human at 1.86 A resolution
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rwv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4rwv RCSB], [http://www.ebi.ac.uk/pdbsum/4rwv PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
[[Category: Joint Center For Structural Genomics (Jcsg), Partnership For Stem Cell Biology, Partnership For Stem Cell Biology (Stemcell)]]
== Function ==
[[http://www.uniprot.org/uniprot/NR5A2_HUMAN NR5A2_HUMAN]] Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development.  
__TOC__
</StructureSection>
[[Category: Biology, Partnership for Stem Cell]]
[[Category: Structural genomic]]
[[Category: STEMCELL, Partnership for Stem Cell Biology]]
[[Category: Jcsg]]
[[Category: Ligand-binding domain of nuclear hormone receptor]]
[[Category: Partnership for stem cell biology]]
[[Category: Pf00104 family]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Transcription]]
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