4ryj: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of apo dimer of BcTSPO==
<StructureSection load='4ryj' size='340' side='right' caption='[[4ryj]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ryj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RYJ FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ryi|4ryi]], [[4rym|4rym]], [[4ryn|4ryn]], [[4ryo|4ryo]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ryj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ryj OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ryj RCSB], [http://www.ebi.ac.uk/pdbsum/4ryj PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Translocator proteins (TSPOs) bind steroids and porphyrins, and they are implicated in many human diseases, for which they serve as biomarkers and therapeutic targets. TSPOs have tryptophan-rich sequences that are highly conserved from bacteria to mammals. Here we report crystal structures for Bacillus cereus TSPO (BcTSPO) down to 1.7 A resolution, including a complex with the benzodiazepine-like inhibitor PK11195. We also describe BcTSPO-mediated protoporphyrin IX (PpIX) reactions, including catalytic degradation to a previously undescribed heme derivative. We used structure-inspired mutations to investigate reaction mechanisms, and we showed that TSPOs from Xenopus and man have similar PpIX-directed activities. Although TSPOs have been regarded as transporters, the catalytic activity in PpIX degradation suggests physiological importance for TSPOs in protection against oxidative stress.


The entry 4ryj is ON HOLD
Protein structure. Structure and activity of tryptophan-rich TSPO proteins.,Guo Y, Kalathur RC, Liu Q, Kloss B, Bruni R, Ginter C, Kloppmann E, Rost B, Hendrickson WA Science. 2015 Jan 30;347(6221):551-5. doi: 10.1126/science.aaa1534. PMID:25635100<ref>PMID:25635100</ref>


Authors: Guo, Y., Liu, Q., Hendrickson, W.A., New York Consortium on Membrane Protein Structure (NYCOMPS)
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: Crystal structure of apo dimer of BcTSPO
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: New York Consortium On Membrane Protein Structure (Nycomps)]]
__TOC__
</StructureSection>
[[Category: Guo, Y]]
[[Category: Guo, Y]]
[[Category: Hendrickson, W A]]
[[Category: Liu, Q]]
[[Category: Liu, Q]]
[[Category: Hendrickson, W.A]]
[[Category: NYCOMPS, New York Consortium on Membrane Protein Structure]]
[[Category: Membrane protein]]
[[Category: New york consortium on membrane protein structure]]
[[Category: Nycomp]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Receptor]]
[[Category: Structural genomic]]
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