4tmr: Difference between revisions
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==Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 99S: methyl 5-{3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl}thiophene-2-carboxylate .== | |||
<StructureSection load='4tmr' size='340' side='right' caption='[[4tmr]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4tmr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TMR FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=99S:METHYL+5-{3-[(4S)-6-AMINO-5-CYANO-3-METHYL-4-(PROPAN-2-YL)-2,4-DIHYDROPYRANO[2,3-C]PYRAZOL-4-YL]-5-CYANOPHENYL}THIOPHENE-2-CARBOXYLATE'>99S</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pff|4pff]], [[4pfn|4pfn]], [[4oyt|4oyt]], [[4o6z|4o6z]], [[4tn4|4tn4]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tmr RCSB], [http://www.ebi.ac.uk/pdbsum/4tmr PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Chitnumsub, P]] | |||
[[Category: Jaruwat, A]] | [[Category: Jaruwat, A]] | ||
[[Category: Leartsakulpanich, U]] | [[Category: Leartsakulpanich, U]] | ||
[[Category: Witschel, M | [[Category: Witschel, M C]] | ||
[[Category: | [[Category: Alpha and beta protein]] | ||
[[Category: Inhibitor]] | |||
[[Category: Methyltransferase activity]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 14:10, 26 March 2015
Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 99S: methyl 5-{3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl}thiophene-2-carboxylate .
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