4try: Difference between revisions
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''' | ==Structure of BACE1 complex with a HEA-type inhibitor== | ||
<StructureSection load='4try' size='340' side='right' caption='[[4try]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4try]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TRY FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=36D:N-[(2R,3S)-3-AMINO-2-HYDROXY-4-(THIOPHEN-2-YL)BUTANOYL]-L-NORVALINE'>36D</scene>, <scene name='pdbligand=TIH:BETA(2-THIENYL)ALANINE'>TIH</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4trw|4trw]], [[4trz|4trz]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4try FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4try OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4try RCSB], [http://www.ebi.ac.uk/pdbsum/4try PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Memapsin 2]] | |||
[[Category: Akaji, K]] | |||
[[Category: Akiyama, T]] | |||
[[Category: Nakagawa, A]] | |||
[[Category: Sanjho, A]] | |||
[[Category: Teruya, K]] | [[Category: Teruya, K]] | ||
[[Category: Yamashita, E]] | [[Category: Yamashita, E]] | ||
[[Category: | [[Category: Designed inhibitor]] | ||
[[Category: | [[Category: Hydrase proteinase converting]] | ||
[[Category: Hydrase-inhibitor complex]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
Revision as of 14:47, 29 July 2015
Structure of BACE1 complex with a HEA-type inhibitor
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