4tu5: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1062)==

~~The entry~~ 4tu5 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4tu5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TU5 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TU5 FirstGlance].

~~Authors~~: ~~Reeve, S~~.M.~~, Anderson, A~~.C.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=06W:6-ETHYL-5-{(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06W</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4tu2|4tu2]]</td></tr>

~~Description~~: ~~Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and~~ 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (~~UCP1062~~)

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tu5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tu5 RCSB], [http://www.ebi.ac.uk/pdbsum/4tu5 PDBsum]</td></tr>

[[Category: Anderson, A.C]]

</table>

[[Category: Reeve, S.M]]

== Function ==

[[http://www.uniprot.org/uniprot/Q2YY41_STAAB Q2YY41_STAAB]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]

__TOC__

</StructureSection>

[[Category: Dihydrofolate reductase]]

[[Category: Anderson, A C]]

[[Category: Reeve, S M]]

[[Category: Antifolate]]

[[Category: Enantiopure inhibitor]]

[[Category: Methicillin-resistant staphylococcus aureus]]

[[Category: Oxidoreductase]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1062)==
+<StructureSection load='4tu5' size='340' side='right' caption='[[4tu5]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
-The entry 4tu5 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4tu5]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TU5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TU5 FirstGlance]. <br>
-Authors: Reeve, S.M., Anderson, A.C.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=06W:6-ETHYL-5-{(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL}PYRIMIDINE-2,4-DIAMINE'>06W</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4tu2|4tu2]]</td></tr>
-Description: Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1062)
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tu5 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tu5 RCSB], [http://www.ebi.ac.uk/pdbsum/4tu5 PDBsum]</span></td></tr>
-[[Category: Anderson, A.C]]
+</table>
-[[Category: Reeve, S.M]]
+== Function ==
+[[http://www.uniprot.org/uniprot/Q2YY41_STAAB Q2YY41_STAAB]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity).[PIRNR:PIRNR000194]
+__TOC__
+</StructureSection>
+[[Category: Dihydrofolate reductase]]
+[[Category: Anderson, A C]]
+[[Category: Reeve, S M]]
+[[Category: Antifolate]]
+[[Category: Enantiopure inhibitor]]
+[[Category: Methicillin-resistant staphylococcus aureus]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]