4use: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:
'''Unreleased structure'''
==Human STK10 (LOK) with SB-633825==
 
<StructureSection load='4use' size='340' side='right' caption='[[4use]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
The entry 4use is ON HOLD  until Paper Publication
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4use]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4USE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4USE FirstGlance]. <br>
Authors: Elkins, J.M., Salah, E., Szklarz, M., vonDelft, F., Canning, P., Raynor, J., Bountra, C., Edwards, A.M., Knapp, S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=R09:4-{5-(6-METHOXYNAPHTHALEN-2-YL)-1-METHYL-2-[2-METHYL-4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL}PYRIDINE'>R09</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4usd|4usd]], [[4usf|4usf]]</td></tr>
Description: Human STK10 (LOK) with SB-633825
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4use FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4use OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4use RCSB], [http://www.ebi.ac.uk/pdbsum/4use PDBsum]</span></td></tr>
[[Category: Elkins, J.M]]
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref> 
== Function ==
[[http://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN]] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Bountra, C]]
[[Category: Canning, P]]
[[Category: Canning, P]]
[[Category: Vondelft, F]]
[[Category: Edwards, A M]]
[[Category: Elkins, J M]]
[[Category: Knapp, S]]
[[Category: Knapp, S]]
[[Category: Bountra, C]]
[[Category: Raynor, J]]
[[Category: Raynor, J]]
[[Category: Salah, E]]
[[Category: Szklarz, M]]
[[Category: Szklarz, M]]
[[Category: Edwards, A.M]]
[[Category: VonDelft, F]]
[[Category: Salah, E]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/4use"