4v38: Difference between revisions
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''' | ==Apo-structure of alpha2,3-sialyltransferase variant 1 from Pasteurella dagmatis== | ||
<StructureSection load='4v38' size='340' side='right' caption='[[4v38]], [[Resolution|resolution]] 1.96Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4v38]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V38 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V38 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2u|4v2u]], [[4v39|4v39]], [[4v3b|4v3b]], [[4v3c|4v3c]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v38 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v38 RCSB], [http://www.ebi.ac.uk/pdbsum/4v38 PDBsum]</span></td></tr> | |||
</table> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Structure-guided active-site redesign of a family GT-80 beta-D-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from alpha-2,3 in the wild type to alpha-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering. | |||
Complete switch from alpha-2,3- to alpha-2,6-regioselectivity in Pasteurella dagmatis beta-D-galactoside sialyltransferase by active-site redesign.,Schmolzer K, Czabany T, Luley-Goedl C, Pavkov-Keller T, Ribitsch D, Schwab H, Gruber K, Weber H, Nidetzky B Chem Commun (Camb). 2015 Feb 21;51(15):3083-6. doi: 10.1039/c4cc09772f. PMID:25619424<ref>PMID:25619424</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Czabany, T]] | |||
[[Category: Gruber, K]] | |||
[[Category: Luley-Goedl, C]] | [[Category: Luley-Goedl, C]] | ||
[[Category: Nidetzky, B]] | [[Category: Nidetzky, B]] | ||
[[Category: Pavkov-Keller, T]] | [[Category: Pavkov-Keller, T]] | ||
[[Category: Ribitsch, D]] | |||
[[Category: Schmoelzer, K]] | [[Category: Schmoelzer, K]] | ||
[[Category: Schwab, H]] | [[Category: Schwab, H]] | ||
[[Category: Transferase]] | |||
Revision as of 11:09, 8 April 2015
Apo-structure of alpha2,3-sialyltransferase variant 1 from Pasteurella dagmatis
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