4v3c: Difference between revisions

Line 1:

'''~~Unreleased~~ structure'''

==The structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis in complex with the donor product CMP==

== Structural highlights ==

<table><tr><td colspan='2'>[[4v3c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V3C FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2u|4v2u]], [[4v38|4v38]], [[4v39|4v39]], [[4v3b|4v3b]]</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v3c RCSB], [http://www.ebi.ac.uk/pdbsum/4v3c PDBsum]</span></td></tr>

</table>

== Publication Abstract from PubMed ==

Structure-guided active-site redesign of a family GT-80 beta-D-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from alpha-2,3 in the wild type to alpha-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering.

~~The entry 4v3c is ON HOLD until Paper Publication~~

Complete switch from alpha-2,3- to alpha-2,6-regioselectivity in Pasteurella dagmatis beta-D-galactoside sialyltransferase by active-site redesign.,Schmolzer K, Czabany T, Luley-Goedl C, Pavkov-Keller T, Ribitsch D, Schwab H, Gruber K, Weber H, Nidetzky B Chem Commun (Camb). 2015 Feb 21;51(15):3083-6. doi: 10.1039/c4cc09772f. PMID:25619424<ref>PMID:25619424</ref>

~~Authors: Pavkov-Keller~~, T.~~, Schmoelzer, K~~.~~, Czabany, T., Luley-Goedl, C., Ribitsch, D., Schwab, H., Nidetzky, B., Gruber, K~~.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>

</div>

~~Description: The structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis in complex with the donor product CMP~~

== References ==

[[Category: ~~Unreleased Structures~~]]

[[Category: ~~Ribitsch~~, D]]

__TOC__

</StructureSection>

[[Category: Czabany, T]]

[[Category: Gruber, K]]

[[Category: Luley-Goedl, C]]

[[Category: Nidetzky, B]]

~~[[Category: Czabany, T]]~~

[[Category: Pavkov-Keller, T]]

[[Category: Ribitsch, D]]

[[Category: Schmoelzer, K]]

~~[[Category: Gruber, K]]~~

[[Category: Schwab, H]]

[[Category: Transferase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis in complex with the donor product CMP==
+<StructureSection load='4v3c' size='340' side='right' caption='[[4v3c]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4v3c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4V3C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4V3C FirstGlance]. <br>
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4v2u|4v2u]], [[4v38|4v38]], [[4v39|4v39]], [[4v3b|4v3b]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4v3c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4v3c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4v3c RCSB], [http://www.ebi.ac.uk/pdbsum/4v3c PDBsum]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Structure-guided active-site redesign of a family GT-80 beta-D-galactoside sialyltransferase (from Pasteurella dagmatis) to change enzyme regioselectivity from alpha-2,3 in the wild type to alpha-2,6 in a P7H-M117A double mutant is reported. Biochemical data for sialylation of lactose together with protein crystal structures demonstrate highly precise enzyme engineering.
-The entry 4v3c is ON HOLD  until Paper Publication
+Complete switch from alpha-2,3- to alpha-2,6-regioselectivity in Pasteurella dagmatis beta-D-galactoside sialyltransferase by active-site redesign.,Schmolzer K, Czabany T, Luley-Goedl C, Pavkov-Keller T, Ribitsch D, Schwab H, Gruber K, Weber H, Nidetzky B Chem Commun (Camb). 2015 Feb 21;51(15):3083-6. doi: 10.1039/c4cc09772f. PMID:25619424<ref>PMID:25619424</ref>
-Authors: Pavkov-Keller, T., Schmoelzer, K., Czabany, T., Luley-Goedl, C., Ribitsch, D., Schwab, H., Nidetzky, B., Gruber, K.
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-Description: The structure of alpha2,3-sialyltransferase variant 2 from Pasteurella dagmatis in complex with the donor product CMP
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Ribitsch, D]]
+__TOC__
+</StructureSection>
+[[Category: Czabany, T]]
+[[Category: Gruber, K]]
 [[Category: Luley-Goedl, C]]
 [[Category: Nidetzky, B]]
-[[Category: Czabany, T]]
 [[Category: Pavkov-Keller, T]]
+[[Category: Ribitsch, D]]
 [[Category: Schmoelzer, K]]
-[[Category: Gruber, K]]
 [[Category: Schwab, H]]
+[[Category: Transferase]]