1z27: Difference between revisions
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1z27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z27 OCA], [http://www.ebi.ac.uk/pdbsum/1z27 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1z27 RCSB]</span> | |||
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[[Category: four egf-like domain]] | [[Category: four egf-like domain]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:27:56 2008'' | ||
Revision as of 22:27, 30 March 2008
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| 1z27, resolution 2.08Å | |||||||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of Native Pvs25, an ookinete protein from Plasmodium vivax.
Overview
P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.
About this Structure
1Z27 is a Single protein structure of sequence from Plasmodium vivax. Full crystallographic information is available from OCA.
Reference
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms., Saxena AK, Singh K, Su HP, Klein MM, Stowers AW, Saul AJ, Long CA, Garboczi DN, Nat Struct Mol Biol. 2006 Jan;13(1):90-1. Epub 2005 Dec 4. PMID:16327807
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