4wnt: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
''' | ==Human Cytochrome P450 2D6 Ajmalicine Complex== | ||
<StructureSection load='4wnt' size='340' side='right' caption='[[4wnt]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4wnt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WNT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WNT FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AJN:AJMALICINE'>AJN</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3tbg|3tbg]], [[3tda|3tda]], [[3qm4|3qm4]], [[2f9q|2f9q]], [[4wnw|4wnw]], [[4wnu|4wnu]], [[4wnv|4wnv]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wnt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wnt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wnt RCSB], [http://www.ebi.ac.uk/pdbsum/4wnt PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/CP2D6_HUMAN CP2D6_HUMAN]] Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants.<ref>PMID:16352597</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Unspecific monooxygenase]] | |||
[[Category: Johnson, E F]] | |||
[[Category: Stout, C D]] | |||
[[Category: Wang, A]] | [[Category: Wang, A]] | ||
[[Category: | [[Category: Cyp2d6]] | ||
[[Category: | [[Category: Cytochrome p450]] | ||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]] | |||
[[Category: P450 2d6]] | |||
Revision as of 13:47, 14 January 2015
Human Cytochrome P450 2D6 Ajmalicine Complex
| ||||||||||||
