4wqp: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist==

~~The entry~~ 4wqp is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4wqp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WQP FirstGlance]. <br>

~~Authors~~: ~~Boenig~~, G., ~~Hymowitz~~, S.G.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SX:N-[4-(4-ACETYLPIPERAZIN-1-YL)BENZYL]-N-(2-METHYLPROPYL)-1-PHENYLMETHANESULFONAMIDE'>3SX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wqp RCSB], [http://www.ebi.ac.uk/pdbsum/4wqp PDBsum]</span></td></tr>

~~Description: Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist~~

</table>

[[~~Category~~: ~~Unreleased Structures~~]]

== Function ==

~~[[Category: Hymowitz~~, S.~~G]]~~

[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.

__TOC__

</StructureSection>

[[Category: Boenig, G]]

[[Category: Hymowitz, S G]]

[[Category: Nuclear receptor ligand binding domain]]

[[Category: Transcription]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist==
+<StructureSection load='4wqp' size='340' side='right' caption='[[4wqp]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
-The entry 4wqp is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4wqp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WQP FirstGlance]. <br>
-Authors: Boenig, G., Hymowitz, S.G.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SX:N-[4-(4-ACETYLPIPERAZIN-1-YL)BENZYL]-N-(2-METHYLPROPYL)-1-PHENYLMETHANESULFONAMIDE'>3SX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wqp RCSB], [http://www.ebi.ac.uk/pdbsum/4wqp PDBsum]</span></td></tr>
-Description: Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Hymowitz, S.G]]
+[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
+__TOC__
+</StructureSection>
 [[Category: Boenig, G]]
+[[Category: Hymowitz, S G]]
+[[Category: Nuclear receptor ligand binding domain]]
+[[Category: Transcription]]